Evan Williams, former CEO of Pyra (creators of Blogger; bought out by Google), writes about running a business on web apps:
One interesting thing about starting a company today versus a few years ago: Lots of cool web apps are now available that you can more or less run you company on.
He goes on to list some of the web applications they are using at Odeo, then writes,
The improved efficiency of having these apps available, and not having to install and maintain servers for them is huge.
Ken Dyck 